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Revista Medica de Chile Sep 2010Among rheumatic diseases and specifically spondyloarthropathies (SpA), the study of biomarkers, defined as molecules that reflect either biologic or specific... (Review)
Review
Among rheumatic diseases and specifically spondyloarthropathies (SpA), the study of biomarkers, defined as molecules that reflect either biologic or specific pathological process, is an important and necessary area in basic and clinical research, being a consequence or the response of an intervention. Other markers provide information about the pathogenesis of this disease. Recently, HLA-B27 has been used as diagnostic criteria to detect SpA. Bath Ankylosing Spondylitis Disease Activity Index (BASDAI) and Bath Ankylosing Spondylitis Functional Index (BASFI) are clinical scores used to assess disease activity. A new activity index, Ankylosing Spondylitis Disease Activity Score (ASDAS) considers erythrocyte sedimentation rate (ESR) and C-reactive protein (CRP) as biomarkers. This review describes the state of the art of research on SpA biomarkers. There are promising new candidates as biomarkers such as metallopro-teinase 3, Type II collagen neoepitopes (C2C and C1-2C), C-propeptide of Type II collagen (CPII), aggrecan 846 epitope, macrophage colony stimulating factor, serum amyloid A protein and interleukin-6, among others.
Topics: Biomarkers; Blood Sedimentation; Humans; Spondylarthropathies
PubMed: 21249289
DOI: No ID Found -
Joint Diseases and Related Surgery Aug 2023This study aims to investigate the reliability of the joint fluid cell count and blood parameters compared to the culture results in the diagnosis of septic arthritis...
OBJECTIVES
This study aims to investigate the reliability of the joint fluid cell count and blood parameters compared to the culture results in the diagnosis of septic arthritis (SA).
PATIENTS AND METHODS
A total of 192 patients (112 males, 80 females, mean age: 60.3±19.2 years; range, 18 to 98 years) who presented with SA between January 2018 and July 2022 were evaluated retrospectively. The recorded joint fluid cell count, complete blood count (CBC), white blood cell (WBC) count, serum erythrocyte sedimentation rate (ESR) and serum C-reactive protein (CRP) and culture results were analyzed comparatively according to SA diagnosis.
RESULTS
The most commonly involved joint was the knee joint (82.3%), which was affected in 158 patients. Thirty-six (18.8%) of the patients who underwent joint aspiration had positive culture result. The cultures were positive in 10 (35.7%) of 28 patients with synovial WBC value greater than 50,000/mm3, while 26 (15.9%) of 164 patients with a synovial WBC value less than 50,000/mm3 had positive culture results (p=0.013).
CONCLUSION
Patients with SA may present variable blood and synovial parameters. Making decision based on the commonly used synovial WBC count cut-off value of 50,000/mm3 may lead to misdiagnosis. To avoid misdiagnosis or delay in treatment, it is of utmost importance not to exclude the diagnosis acutely, and suspicion of SA should remain even with unlikely values.
Topics: Female; Male; Humans; Adult; Middle Aged; Aged; Reproducibility of Results; Retrospective Studies; Leukocyte Count; Arthritis, Infectious; Blood Sedimentation
PubMed: 37750279
DOI: 10.52312/jdrs.2023.1222 -
Medical Gas Research 2022Coronavirus disease 2019 (COVID-19) triggers important changes in routine blood tests. In this retrospective case-control study, biochemical, hematological and...
Coronavirus disease 2019 (COVID-19) triggers important changes in routine blood tests. In this retrospective case-control study, biochemical, hematological and inflammatory biomarkers between March 10, 2020, and November 30, 2020 from 3969 COVID-19 patients (3746 in the non-intensive care unit (non-ICU) group and 223 in the ICU group) were analyzed by dividing into three groups as spring, summer and autumn. In the non-ICU group, lymphocyte to monocyte ratio was lower in autumn than the other two seasons and neutrophil to lymphocyte ratio was higher in autumn than the other two seasons. Also, monocyte and platelet were higher in spring than autumn; and eosinophil, hematocrit, hemoglobin, lymphocyte, and red blood cells decreased from spring to autumn. In the non-ICU group, alanine aminotransferase and gamma-glutamyltransferase gradually increased from spring to autumn, while albumin, alkaline phosphatase, calcium, total bilirubin and total protein gradually decreased. Additionally, C-reactive protein was higher in autumn than the other seasons, erythrocyte sedimentation rate was higher in autumn than summer. The changes in routine blood biomarkers in COVID-19 varied from the emergence of the disease until now. Also, the timely changes of blood biomarkers were mostly more negative, indicating that the disease progresses severely. The study was approved by the Erzincan Binali Yildirim University Non-interventional Clinical Trials Ethic Committee (approval No. 86041) on June 21, 2021.
Topics: Aged; Blood Sedimentation; COVID-19; Case-Control Studies; Humans; Retrospective Studies; SARS-CoV-2
PubMed: 34677152
DOI: 10.4103/2045-9912.325992 -
Biochemia Medica 2013Today, the pneumatic tube transport system (PTS) is used frequently because of its advantages related to timing and speed. However, the impact of various types of PTS on...
INTRODUCTION
Today, the pneumatic tube transport system (PTS) is used frequently because of its advantages related to timing and speed. However, the impact of various types of PTS on blood components is unknown. The aim of this study was to examine the influence of PTS on the quality of routine blood cell counts, erythrocyte sedimentation, and certain blood coagulation tests.
MATERIALS AND METHODS
Paired blood samples were obtained from each of 45 human volunteers and evaluated by blood cell count, erythrocyte sedimentation, and several coagulation tests, including prothrombin time (PT) and activated partial thromboplastin time (aPTT). Blood samples were divided into 2 groups: Samples from group 1 were transported to the laboratory via the PTS, and samples from group 2 were transported to the laboratory manually. Both groups were evaluated immediately by the tests listed above.
RESULTS
The blood sample test results from groups 1 and 2 were evaluated and compared. Nostatistically significant differences were observed (P = 0.069-0.977).
CONCLUSION
The PTS yielded no observable effects on blood cell counts, erythrocyte sedimentation, or PT and aPTT test results. We concluded that the PTS can be used to transport blood samples and yield reliable results for blood cell counts, erythrocyte sedimentation, and several coagulation tests.
Topics: Blood Cell Count; Blood Coagulation Tests; Blood Sedimentation; Cross-Sectional Studies; Equipment and Supplies; Humans; Prospective Studies; Specimen Handling
PubMed: 23894866
DOI: 10.11613/bm.2013.024 -
Revue Medicale de Liege May 2022Biomarkers of inflammation such as sedimentation rate, C-reactive protein and procalcitonin are used in daily clinical practice for the diagnosis, prognosis and...
Biomarkers of inflammation such as sedimentation rate, C-reactive protein and procalcitonin are used in daily clinical practice for the diagnosis, prognosis and follow-up of patients with fever or inflammatory syndrome. The purpose of this article is to summarize the current knowledge about these main biological tests and to discuss new biomarkers and new assay approaches such as multiplex technology.
Topics: Biomarkers; Blood Sedimentation; C-Reactive Protein; Calcitonin; Humans; Inflammation
PubMed: 35657180
DOI: No ID Found -
British Medical Journal Apr 1971
Topics: Arteritis; Arthritis, Rheumatoid; Blood Sedimentation; Foot Diseases; Humans; Neural Conduction; Paralysis; Paresthesia; Penicillamine; Peripheral Nervous System Diseases; Steroids; gamma-Globulins
PubMed: 4103337
DOI: No ID Found -
British Medical Journal Jan 1971
Topics: Angiography; Blood Sedimentation; Heart Atria; Heart Neoplasms; Humans; Myxoma; Serum Globulins
PubMed: 5539175
DOI: No ID Found -
British Medical Journal Apr 1969
Topics: Blood Sedimentation; Humans; Polymyalgia Rheumatica; Prednisolone; Prednisone
PubMed: 5775460
DOI: 10.1136/bmj.2.5649.99 -
Annals of the Rheumatic Diseases May 1968
Topics: Adult; Age Factors; Aged; Agglutination Tests; Arthritis, Rheumatoid; Blood Sedimentation; Female; Humans; Lymph Nodes; Lymphography; Male; Middle Aged; Sex Factors; Time Factors
PubMed: 5655317
DOI: 10.1136/ard.27.3.253 -
BMC Musculoskeletal Disorders Mar 2022Although many markers are used for diagnosis of periprosthetic joint infection (PJI), serological screening and diagnosis for PJI are still challenging. We evaluated the...
BACKGROUND
Although many markers are used for diagnosis of periprosthetic joint infection (PJI), serological screening and diagnosis for PJI are still challenging. We evaluated the performance of serum D-lactate and compared it with ESR, coagulation-related biomarkers and synovial D-lactate for the diagnosis of PJI.
METHODS
Consecutive patients with preoperative blood and intraoperative joint aspiration of a prosthetic hip or knee joint before revision arthroplasty were prospectively included. The diagnosis of PJI was based on the criteria of the Musculoskeletal Infection Society, and the diagnostic values of markers were estimated based on receiver operating characteristic (ROC) curves by maximizing sensitivity and specificity using optimal cutoff values.
RESULTS
Of 52 patients, 26 (50%) were diagnosed with PJI, and 26 (50%) were diagnosed with aseptic failure. ROC curves showed that serum D-lactate, fibrinogen (FIB) and ESR had equal areas under the curve (AUCs) of 0.80, followed by D-dimer and fibrin degradation product, which had AUCs of 0.67 and 0.69, respectively. Serum D-lactate had the highest sensitivity of 88.46% at the optimal threshold of 1.14 mmol/L, followed by FIB and ESR, with sensitivities of 80.77% and 73.08%, respectively, while there were no significant differences in specificity (73.08%, 73.08% and 76.92%, respectively).
CONCLUSION
Serum D-lactate showed similar performance to FIB and ESR for diagnosis of PJI. The advantages of serum D-lactate are pathogen-specific, highly sensitive, minimally invasive and rapidly available making serum D-lactate useful as a point-of-care screening test for PJI.
Topics: Arthroplasty, Replacement, Hip; Biomarkers; Blood Sedimentation; C-Reactive Protein; Humans; Lactic Acid; Prosthesis-Related Infections
PubMed: 35346149
DOI: 10.1186/s12891-022-05199-8